Chronic myelogenous leukemia (CML) is a form of leukemia that progresses gradually over time as opposed to developing rapidly, as in cases of acute myelogenous leukemia. Approximately 4,600 cases of CML leukemia are diagnosed in the U.S. every year. Most cases of chronic myelogenous leukemia are diagnosed in adults.
Chronic myelogenous leukemia is a type of blood cancer in which the bone marrow produces too many white blood cells called “granulocytes.” Some of these cells never mature into white blood cells. These “immature” or “primitive” white blood cells are called “blasts.” Over time, the granulocytes and blasts grow out of control and result in a reduced number of platelets and red blood cells in the bone marrow. This can lead to such symptoms as chronic fatigue, fever and night sweats, unexplained weight loss, and pain or pressure on the left side of the abdomen, where the spleen is located. Unlike acute forms of leukemia, the bone marrow continues to make mature white blood cells that can function normally for a significant period of time, at least in the early phase of CML.
CML results from an acquired (not inherited) injury to the DNA of a stem cell in the bone marrow. Most people with CML have a gene mutation called the “Philadelphia chromosome.” This chromosome causes the bone marrow to make a certain type of enzyme that results in the development of granulocytes or blasts. Benzene exposure can be a cause of CML.
There are several “subtypes” of CML, including chronic myelogenous leukemia, chronic myeloid leukemia, chronic myelocytic leukemia, and chronic granulocytic leukemia (CGL).
The symptoms of chronic myelogenous leukemia typically develop over time. The following is a list of possible CML symptoms:
Anemia
Chronic fatigue
Unexpected weight loss
Discomfort on the left side of the abdomen
Excessive sweating, night sweats, and/or inability to tolerate warm temperatures
For over 29 years, the law firm of Baron & Budd, P.C. has fought to safeguard the rights of victims of toxic substances like benzene. The Leukemia Lawyer Web site is a service of Baron & Budd, P.C.
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